This boutique bolt-hole, found on a quiet alley between Piazza San Marco and the Rialto, was so liked by Johnny Depp that he took over the best suite for three months while filming The Tourist, turning the exclusive Krug Lounge into his living room.
The 16th-century façade belies its Philippe Starck-designed jewel-box interior, with 26 mirror-lined rooms.
The PGs Club Restaurant is decked out in sumptuous fabrics, Murano glass chandeliers and furniture that echoes the boats bobbing on the canal.
Bacari (wine bars) line the streets, serving prosecco and cicheti (tapas), or the concierge can book an evening in a palazzo with your own chef.
WOW FACTOR: The cosy library, with open log fire, cashmere blankets and views directly over the Grand Canal.
GO: Mr & Mrs Smith (mrandmrssmith.com) offers doubles from £279. British Airways (britishairways.com) flies from £98 return.